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FROM THIS EPISODE

The greatest mysteries all have a shadowy figure at the center-someone who sets things in motion and holds the key to how the rest of the story unfolds. In epidemiology, this central character is known as Patient Zero-the case at the heart of an outbreak. This hour, we hunt for Patient Zeroes from all over the map-from the origins of a blues legend, to the history of the high five, to a race to halt the spread of a deadly disease.

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