John C. Reilly on playing a contract killer with a heart of gold

During the Gold Rush of 1851, the Sisters Brothers are killers for hire. They have daddy issues. They’re being shot at constantly. One of them drinks too much. They fight. Charlie Sisters, the live-wire, is played by Joaquin Phoenix. His big brother Eli, the gentler and more sensible one, is played by John C. Reilly. We talk to Reilly about his new movie and the response to it.

John C. Reilly at KCRW. Photos by Amy Ta.